Pub. Date : 2022
PMID : 35496911
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heme Oxygenase-1 Protects Hair Cells From Gentamicin-Induced Death. | Gentamicins | heme oxygenase 1 | Homo sapiens |
| 2 | We found that during gentamicin-induced death in HCs, Heme oxygenase-1 (HO-1) had a high fold change in the HCs of the cochlea. | Gentamicins | heme oxygenase 1 | Homo sapiens |
| 3 | We found that during gentamicin-induced death in HCs, Heme oxygenase-1 (HO-1) had a high fold change in the HCs of the cochlea. | Gentamicins | heme oxygenase 1 | Homo sapiens |
| 4 | Moreover, the use of CoPPIX to induce HO-1 inhibited gentamicin-induced HC death, while HO-1 inhibitors ZnPPIX after CoPPIX reversed this process. | Gentamicins | heme oxygenase 1 | Homo sapiens |
| 5 | Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity. | Gentamicins | heme oxygenase 1 | Homo sapiens |
| 6 | Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity. | Gentamicins | heme oxygenase 1 | Homo sapiens |
| 7 | Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity. | Gentamicins | heme oxygenase 1 | Homo sapiens |
| 8 | Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity. | Gentamicins | heme oxygenase 1 | Homo sapiens |
| 9 | Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity. | Gentamicins | heme oxygenase 1 | Homo sapiens |
| 10 | Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity. | Gentamicins | heme oxygenase 1 | Homo sapiens |
| 11 | In summary, these findings indicated that HO-1 protects HCs from gentamicin by up-regulating its expression in HCs and interacting with Nrf2 to inhibit reactive oxygen species (ROS). | Gentamicins | heme oxygenase 1 | Homo sapiens |