PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35496911-0	2022	Heme Oxygenase-1 Protects Hair Cells From Gentamicin-Induced Death.	Gentamicins	42-52	heme oxygenase 1	Homo sapiens	0-16	
35496911-4	2022	We found that during gentamicin-induced death in HCs, Heme oxygenase-1 (HO-1) had a high fold change in the HCs of the cochlea.	Gentamicins	21-31	heme oxygenase 1	Homo sapiens	54-70	
35496911-4	2022	We found that during gentamicin-induced death in HCs, Heme oxygenase-1 (HO-1) had a high fold change in the HCs of the cochlea.	Gentamicins	21-31	heme oxygenase 1	Homo sapiens	72-76	
35496911-5	2022	Moreover, the use of CoPPIX to induce HO-1 inhibited gentamicin-induced HC death, while HO-1 inhibitors ZnPPIX after CoPPIX reversed this process.	Gentamicins	53-63	heme oxygenase 1	Homo sapiens	38-42	
35496911-6	2022	Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity.	Gentamicins	142-152	heme oxygenase 1	Homo sapiens	87-91	
35496911-6	2022	Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity.	Gentamicins	142-152	heme oxygenase 1	Homo sapiens	131-135	
35496911-6	2022	Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity.	Gentamicins	142-152	heme oxygenase 1	Homo sapiens	184-188	
35496911-6	2022	Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity.	Gentamicins	209-219	heme oxygenase 1	Homo sapiens	87-91	
35496911-6	2022	Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity.	Gentamicins	209-219	heme oxygenase 1	Homo sapiens	131-135	
35496911-6	2022	Furthermore, the inhibitors of NF-E2-related factor-2 (Nrf2) reduced the expression of HO-1 and inhibited the protective effect of HO-1 after gentamicin, thus suggesting that the Nrf2/HO-1 axis might regulate gentamicin-associated ototoxicity.	Gentamicins	209-219	heme oxygenase 1	Homo sapiens	184-188	
35496911-8	2022	In summary, these findings indicated that HO-1 protects HCs from gentamicin by up-regulating its expression in HCs and interacting with Nrf2 to inhibit reactive oxygen species (ROS).	Gentamicins	65-75	heme oxygenase 1	Homo sapiens	42-46