Pub. Date : 2022 May
PMID : 35472370
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. | Sevoflurane | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | We attempted to indicate whether sevoflurane could activate the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR)-mediated autophagy to attenuate anesthetics-induced neuronal injury in this study. | Sevoflurane | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | We attempted to indicate whether sevoflurane could activate the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR)-mediated autophagy to attenuate anesthetics-induced neuronal injury in this study. | Sevoflurane | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | Further examination revealed that sevoflurane-induced autophagy was mediated by the AMPK/mTOR signaling pathway, with increased p-AMPK expression and decreased p-mTOR expression. | Sevoflurane | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | Further examination revealed that sevoflurane-induced autophagy was mediated by the AMPK/mTOR signaling pathway, with increased p-AMPK expression and decreased p-mTOR expression. | Sevoflurane | mechanistic target of rapamycin kinase | Homo sapiens |
| 6 | Collectively, these results indicated that sevoflurane activates autophagy by regulating the AMPK/mTOR signaling pathway, which is protective against sevoflurane-induced damage in SH-SY5Y cells. | Sevoflurane | mechanistic target of rapamycin kinase | Homo sapiens |