Pub. Date : 2022 Jun
PMID : 35445730
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EGFR inhibition reverses epithelial-mesenchymal transition, and decreases tamoxifen resistance via Snail and Twist downregulation in breast cancer cells. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 2 | In addition, it was observed that the inhibition of epidermal growth factor receptor (EGFR) reversed the EMT phenotype in tamoxifen-resistant MCF7 (MCF-7/TR) cells via the downregulation of Snail and Twist. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 3 | In addition, it was observed that the inhibition of epidermal growth factor receptor (EGFR) reversed the EMT phenotype in tamoxifen-resistant MCF7 (MCF-7/TR) cells via the downregulation of Snail and Twist. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 4 | Notably, the EGFR inhibitor, gefitinib, decreased tamoxifen resistance, migration and invasion through the inhibition of Snail and Twist. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |
| 5 | On the whole, the results of the present study suggest that EGFR may be a promising therapeutic target for tamoxifen-resistant breast cancer. | Tamoxifen | epidermal growth factor receptor | Homo sapiens |