Title : Catalytic asymmetric synthesis of enantioenriched α-deuterated pyrrolidine derivatives.

Pub. Date : 2022 Apr 6

PMID : 35440992






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Notably, the synthetic utility of a reversed 1,3-DC/(H/D-Ex) protocol has been demonstrated by catalytic asymmetric synthesis of deuterium-labelled MDM2 antagonist idasanutlin (RG7388) with high deuterium incorporation. RG7388 MDM2 proto-oncogene Homo sapiens
2 Notably, the synthetic utility of a reversed 1,3-DC/(H/D-Ex) protocol has been demonstrated by catalytic asymmetric synthesis of deuterium-labelled MDM2 antagonist idasanutlin (RG7388) with high deuterium incorporation. RG7388 MDM2 proto-oncogene Homo sapiens