| Protein Name | MDM2 proto-oncogene |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4193 |
| Gene Symbol | MDM2 |
| UniProt | Q00987 (MDM2_HUMAN), G3XA89 (G3XA89_HUMAN), A7UKX8 (A7UKX8_HUMAN), A0A0A8KB75 (A0A0A8KB75_HUMAN), A7UKX7 (A7UKX7_HUMAN), A7UKX9 (A7UKX9_HUMAN), Q96DS0 (Q96DS0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
873
Total Number of Articles : 1430 |
Description |
MDM2 proto-oncogene |
| Gene Summary |
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] |
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| Properties | |