Title : Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.

Pub. Date : 2022 Apr 28

PMID : 35420431






1 Functional Relationships(s)
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1 In three MDM4-overexpressing cancer cell lines harboring wild-type p53, 31 shows improved cell growth inhibition activities compared to RG7388, an MDM2-selective inhibitor in late-stage clinical trials. RG7388 MDM2 proto-oncogene Homo sapiens