Title : Prostaglandin E2-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation.

Pub. Date : 2022 Apr 15

PMID : 35379745






1 Functional Relationships(s)
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1 Here we demonstrated that the EP4-mediated activation of AKT by PGE2 was required for the proper control of inositol-requiring transmembrane kinase endoribonuclease-1alpha (IRE1alpha) hyperactivation and hence the endoplasmic reticulum (ER) homeostasis in IgM-producing SLPCs. Inositol endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus