PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35379745-2 2022 Here we demonstrated that the EP4-mediated activation of AKT by PGE2 was required for the proper control of inositol-requiring transmembrane kinase endoribonuclease-1alpha (IRE1alpha) hyperactivation and hence the endoplasmic reticulum (ER) homeostasis in IgM-producing SLPCs. Inositol 108-116 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 173-182