Protein Name endoplasmic reticulum to nucleus signalling 1
Organism Mus musculus
Gene ID 78943
Gene Symbol

Ern1

UniProt Q9EQY0 (ERN1_MOUSE)
Relationships Total Number of functionally related compound(s) : 162
Total Number of Articles : 199
Description

endoplasmic reticulum to nucleus signalling 1

Gene Summary

Enables endoribonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including IRE1-mediated unfolded protein response; mRNA cleavage; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within endoplasmic reticulum unfolded protein response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and protein autophosphorylation. Located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Part of AIP1-IRE1 complex. Is expressed in several structures, including brain; connective tissue; gut; hemolymphoid system gland; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • serine/threonine-protein kinase/endoribonuclease IRE1
  • endoplasmic reticulum (ER) to nucleus signalling 1
  • endoplasmic reticulum-to-nucleus signaling 1
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Properties