| Protein Name | endoplasmic reticulum to nucleus signalling 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 78943 |
| Gene Symbol | Ern1 |
| UniProt | Q9EQY0 (ERN1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
162
Total Number of Articles : 199 |
Description |
endoplasmic reticulum to nucleus signalling 1 |
| Gene Summary |
Enables RNA endonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including intracellular signal transduction; positive regulation of JNK cascade; and positive regulation of RNA splicing. Acts upstream of or within endoplasmic reticulum unfolded protein response and negative regulation of intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Part of AIP1-IRE1 complex. Is expressed in several structures, including brain; connective tissue; hemolymphoid system gland; long bone; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1). [provided by Alliance of Genome Resources, Jul 2025] |
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