Title : In vitro inactivation of methionine synthase by nitrous oxide.

Pub. Date : 1986 Dec 5

PMID : 3536916






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In vitro inactivation of methionine synthase by nitrous oxide. Nitrous Oxide 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens
2 Prolonged exposure to N2O leads to megaloblastic anemia in humans and to loss of methionine synthase activity in vertebrates. Nitrous Oxide 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens
3 We now report that purified preparations of cobalamin-dependent methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase, EC 2.1.1.13) from both Escherichia coli and pig liver are irreversibly inactivated during turnover in buffers saturated with N2O. Nitrous Oxide 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens