Protein Name 5-methyltetrahydrofolate-homocysteine methyltransferase
Organism Homo sapiens
Gene ID 4548
Gene Symbol

MTR

UniProt Q99707 (METH_HUMAN), A0A6Q8PGK3 (A0A6Q8PGK3_HUMAN)
Relationships Total Number of functionally related compound(s) : 156
Total Number of Articles : 361
Description

5-methyltetrahydrofolate-homocysteine methyltransferase

Gene Summary

This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

synonyms
  • methionine synthase
  • 5-methyltetrahydrofolate-homocysteine methyltransferase 1
  • cobalamin-dependent methionine synthase
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Properties