PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3536916-0 1986 In vitro inactivation of methionine synthase by nitrous oxide. Nitrous Oxide 48-61 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 25-44 3536916-2 1986 Prolonged exposure to N2O leads to megaloblastic anemia in humans and to loss of methionine synthase activity in vertebrates. Nitrous Oxide 22-25 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 81-100 3536916-3 1986 We now report that purified preparations of cobalamin-dependent methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase, EC 2.1.1.13) from both Escherichia coli and pig liver are irreversibly inactivated during turnover in buffers saturated with N2O. Nitrous Oxide 267-270 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 64-83