Pub. Date : 2022 Mar 7
PMID : 35330134
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we utilize homology modelling and molecular docking analysis to determine the binding affinity and the potential interaction sites of MRP1 with Carboplatin, Gemcitabine, Doxorubicin, Paclitaxel, and Topotecan. | Carboplatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Paclitaxel has shown the highest binding affinity whereas Carboplatin displayed the lowest affinity to MRP1. | Carboplatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Interestingly, our data showed that Carboplatin, Paclitaxel, and Topotecan bind specifically to Asn510 residue in the transmembrane domains 1 of the MRP1. | Carboplatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Our results suggest that Carboplatin could be an appropriate therapeutic choice against MRP1 in OC as it couples weakly with Carboplatin. | Carboplatin | ATP binding cassette subfamily B member 1 | Homo sapiens |