PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35330134-3 2022 In this study, we utilize homology modelling and molecular docking analysis to determine the binding affinity and the potential interaction sites of MRP1 with Carboplatin, Gemcitabine, Doxorubicin, Paclitaxel, and Topotecan. Carboplatin 159-170 ATP binding cassette subfamily B member 1 Homo sapiens 149-153 35330134-6 2022 Paclitaxel has shown the highest binding affinity whereas Carboplatin displayed the lowest affinity to MRP1. Carboplatin 58-69 ATP binding cassette subfamily B member 1 Homo sapiens 103-107 35330134-7 2022 Interestingly, our data showed that Carboplatin, Paclitaxel, and Topotecan bind specifically to Asn510 residue in the transmembrane domains 1 of the MRP1. Carboplatin 36-47 ATP binding cassette subfamily B member 1 Homo sapiens 149-153 35330134-8 2022 Our results suggest that Carboplatin could be an appropriate therapeutic choice against MRP1 in OC as it couples weakly with Carboplatin. Carboplatin 125-136 ATP binding cassette subfamily B member 1 Homo sapiens 88-92