Pub. Date : 2022 Apr 15
PMID : 35319066
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | First, we have demonstrated that menadione and plumbagin inhibit the nucleolar NAD+-dependent deacetylase Sirtuin 7 in vitro. | plumbagin | sirtuin 7 | Homo sapiens |
| 2 | As assessed by their inhibitions of rDNA transcription, pre-rRNA processing and formation of etoposide-induced 53BP1 foci, menadione and plumbagin inhibit also Sirtuin 7 catalytic activity in vivo. | plumbagin | sirtuin 7 | Homo sapiens |
| 3 | Second, we have established that in experimental conditions in which the sulfhydryl arylation by menadione or plumbagin is prevented by the thiol reducing agent N-acetyl-L-cysteine, the inhibition of Sirtuin 7 catalytic activity is also prevented. | plumbagin | sirtuin 7 | Homo sapiens |
| 4 | Finally, we discuss here how inhibition of Sirtuin 7 might be critical in determining menadione or plumbagin as anti-tumor agents that can be used in combination in anti-tumoral strategies. | plumbagin | sirtuin 7 | Homo sapiens |