Pub. Date : 2022
PMID : 35295720
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Carveol Promotes Nrf2 Contribution in Depressive Disorders through an Anti-inflammatory Mechanism. | carveol | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 2 | The present study is attempted to examine whether carveol could affect lipopolysaccharide- (LPS-) induced depression, and if so, how nuclear factor E2-related factor (Nrf2) contributed to the neuroprotective effects of carveol mechanistically. | carveol | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 3 | The present study is attempted to examine whether carveol could affect lipopolysaccharide- (LPS-) induced depression, and if so, how nuclear factor E2-related factor (Nrf2) contributed to the neuroprotective effects of carveol mechanistically. | carveol | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 4 | Two experimental cohorts were used using the SD rats: first to evaluate the promising dose of carveol (whether 20 mg/kg or 50 mg/kg) and secondly to determine the effect of carveol on Nrf2-mediated antidepression. | carveol | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 5 | Carveol (20 mg/kg) significantly ameliorated these detrimental effects by promoting the antioxidant Nrf2 gene and protein, which critically regulate the downstream antioxidant and anti-inflammatory pathway. | carveol | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 6 | Our results demonstrated that carveol (20 mg/kg) could activate the endogenous antioxidant Nrf2, which regulates the downstream antioxidant signaling pathway, eventually leading to amelioration of LPS-induced neuroinflammation and neurodegeneration. | carveol | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |