Title : Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1.

Pub. Date : 2022 Apr 5

PMID : 35287432






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 First, we report studies of solvent isotope effects for the N202S CYP17A1 mutant in the presence of 17OH-PREG and 17OH-PROG, which suggest that the ferric peroxo species is the predominant catalytically active intermediate in the lyase step. 17-alpha-Hydroxypregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens