PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35287432-6 2022 First, we report studies of solvent isotope effects for the N202S CYP17A1 mutant in the presence of 17OH-PREG and 17OH-PROG, which suggest that the ferric peroxo species is the predominant catalytically active intermediate in the lyase step. 17-alpha-Hydroxypregnenolone 100-109 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 66-73