Title : Metformin Downregulates the Expression of Epidermal Growth Factor Receptor Independent of Lowering Blood Glucose in Oral Squamous Cell Carcinoma.

Pub. Date : 2022

PMID : 35222283






5 Functional Relationships(s)
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1 Metformin Downregulates the Expression of Epidermal Growth Factor Receptor Independent of Lowering Blood Glucose in Oral Squamous Cell Carcinoma. Metformin epidermal growth factor receptor Homo sapiens
2 The patients were divided into groups according to whether they were taking metformin for the treatment of T2DM, and the expression of EGFR in different groups was compared. Metformin epidermal growth factor receptor Homo sapiens
3 Results: EGFR expression in T2DM patients with OSCC taking metformin was significantly lower than that in the non-metformin group. Metformin epidermal growth factor receptor Homo sapiens
4 In patients with recurrent OSCC with normal blood glucose, metformin remarkably reduced the expression of EGFR in recurrent OSCC tissues. Metformin epidermal growth factor receptor Homo sapiens
5 Conclusion: Metformin may regulate the expression of EGFR in a way that does not rely on lowering blood glucose. Metformin epidermal growth factor receptor Homo sapiens