Title : AP-4-mediated axonal transport controls endocannabinoid production in neurons.

Pub. Date : 2022 Feb 25

PMID : 35217685






4 Functional Relationships(s)
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1 Here we identify DAGLB (diacylglycerol lipase-beta), a key enzyme for generation of the endocannabinoid 2-AG (2-arachidonoylglycerol), as a cargo of AP-4 vesicles. glyceryl 2-arachidonate transcription factor AP-4 Homo sapiens
2 Here we identify DAGLB (diacylglycerol lipase-beta), a key enzyme for generation of the endocannabinoid 2-AG (2-arachidonoylglycerol), as a cargo of AP-4 vesicles. glyceryl 2-arachidonate transcription factor AP-4 Homo sapiens
3 We show that DAGLB accumulates at the trans-Golgi network of AP-4-deficient cells, that axonal DAGLB levels are reduced in neurons from a patient with AP-4 deficiency, and that 2-AG levels are reduced in the brains of AP-4 knockout mice. glyceryl 2-arachidonate transcription factor AP-4 Homo sapiens
4 We show that DAGLB accumulates at the trans-Golgi network of AP-4-deficient cells, that axonal DAGLB levels are reduced in neurons from a patient with AP-4 deficiency, and that 2-AG levels are reduced in the brains of AP-4 knockout mice. glyceryl 2-arachidonate transcription factor AP-4 Homo sapiens