Title : ER Stress is Involved in Mast Cells Degranulation via IRE1α/miR-125/Lyn Pathway in an Experimental Intracerebral Hemorrhage Mouse Model.

Pub. Date : 2022 Jun

PMID : 35171433






1 Functional Relationships(s)
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1 Inhibition of IRE1alpha, with STF083010, remarkably reduced brain water content, improved neurological function, decreased hematoma volume, upregulated the expression of miR-125b-2-3p, decreased the number of mast cells, and downregulated the protein expression of Lyn kinase, XBP1s (spliced X-box binding protein-1), tryptase, IL-17A and TNF-alpha. STF 083010 tumor necrosis factor Mus musculus