Pub. Date : 2022
PMID : 35116094
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Liensinine Inhibits Osteosarcoma Growth by ROS-Mediated Suppression of the JAK2/STAT3 Signaling Pathway. | Reactive Oxygen Species | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | Additionally, liensinine promoted intracellular ROS production, enhanced the GSSG/GSH ratio, and induced MMP loss and ROS-mediated suppression of the JAK2/STAT3 pathway. | Reactive Oxygen Species | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | In conclusion, liensinine-induced ROS production could suppress the activation of the JAK2/STAT3 pathway and inhibit the OS growth both in vivo and in vitro. | Reactive Oxygen Species | signal transducer and activator of transcription 3 | Mus musculus |