Pub. Date : 2022 Jan-Dec
PMID : 35090381
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We developed an IgG4-type monoclonal antibody against human TIGIT, designated as MG1131, using a phage display library of single-chain variable fragments (scFvs). | mg1131 | T cell immunoreceptor with Ig and ITIM domains | Homo sapiens |
| 2 | MG1131 interacts with TIGIT much more tightly than PVR does. | mg1131 | T cell immunoreceptor with Ig and ITIM domains | Homo sapiens |
| 3 | The crystal structure of a scFv version of MG1131 bound to TIGIT was determined, showing that MG1131 could block the PVR-TIGIT interaction and thus the immunosuppressive signaling of TIGIT. | mg1131 | T cell immunoreceptor with Ig and ITIM domains | Homo sapiens |
| 4 | The crystal structure of a scFv version of MG1131 bound to TIGIT was determined, showing that MG1131 could block the PVR-TIGIT interaction and thus the immunosuppressive signaling of TIGIT. | mg1131 | T cell immunoreceptor with Ig and ITIM domains | Homo sapiens |
| 5 | The crystal structure of a scFv version of MG1131 bound to TIGIT was determined, showing that MG1131 could block the PVR-TIGIT interaction and thus the immunosuppressive signaling of TIGIT. | mg1131 | T cell immunoreceptor with Ig and ITIM domains | Homo sapiens |
| 6 | The crystal structure of a scFv version of MG1131 bound to TIGIT was determined, showing that MG1131 could block the PVR-TIGIT interaction and thus the immunosuppressive signaling of TIGIT. | mg1131 | T cell immunoreceptor with Ig and ITIM domains | Homo sapiens |
| 7 | The crystal structure of a scFv version of MG1131 bound to TIGIT was determined, showing that MG1131 could block the PVR-TIGIT interaction and thus the immunosuppressive signaling of TIGIT. | mg1131 | T cell immunoreceptor with Ig and ITIM domains | Homo sapiens |
| 8 | The crystal structure of a scFv version of MG1131 bound to TIGIT was determined, showing that MG1131 could block the PVR-TIGIT interaction and thus the immunosuppressive signaling of TIGIT. | mg1131 | T cell immunoreceptor with Ig and ITIM domains | Homo sapiens |
| 9 | Consistently, MG1131 is bound to TIGIT-expressing cells and interferes with PVR binding to these cells. | mg1131 | T cell immunoreceptor with Ig and ITIM domains | Homo sapiens |