Protein Name T cell immunoreceptor with Ig and ITIM domains
Organism Homo sapiens
Gene ID 201633
Gene Symbol

TIGIT

UniProt Q495A1 (TIGIT_HUMAN)
Relationships Total Number of functionally related compound(s) : 31
Total Number of Articles : 49
Description

T cell immunoreceptor with Ig and ITIM domains

Gene Summary

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]

synonyms
  • T-cell immunoreceptor with Ig and ITIM domains
  • V-set and immunoglobulin domain containing 9
  • V-set and immunoglobulin domain-containing protein 9
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Properties