Title : Saikosaponin-D Mitigates Oxidation in SH-SY5Y Cells Stimulated by Glutamate Through Activation of Nrf2 Pathway: Involvement of PI3K.

Pub. Date : 2022 Feb

PMID : 34994954






1 Functional Relationships(s)
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1 Furthermore, addition of LY294002, a selective inhibitor of PI3K (phosphatidylinositol 3 kinase), blocked saikosaponin-D-caused Nrf2 nuclear translocation and reversed the protection of saikosaponin-D against glutamate in SH-SY5Y cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens