Title : Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms.

Pub. Date : 2021 Dec 10

PMID : 34943075






2 Functional Relationships(s)
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1 Furthermore, the Rg3-reverted SIRT1/PGC-1alpha/SIRT3 activation mediated the repression of p38 MAPK, which downregulated the NF-kappaB translocation in the TNF-alpha-treated cells. ginsenoside Rg3 nuclear factor kappa B subunit 1 Homo sapiens
2 Our results revealed that administration of Rg3 diminished the production of interleukin 8 (IL-8) and matrix metallopeptidase 9 (MMP-9) in chondrocytes via SIRT1/PGC-1alpha/SIRT3/p38 MAPK/NF-kappaB signaling in response to TNF-alpha stimulation. ginsenoside Rg3 nuclear factor kappa B subunit 1 Homo sapiens