Pub. Date : 2022 Apr
PMID : 34890285
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergistic Inhibitory Effects of 5-Aza-2"-Deoxycytidine and Cisplatin on Urothelial Carcinoma Growth via Suppressing TGFBI-MAPK Signaling Pathways. | Cisplatin | transforming growth factor beta induced | Homo sapiens |
| 2 | The results showed that several key regulatory genes, such as interleukin 24(IL24), fibroblast growth factor 1(FGF1), and transforming growth factor beta-induced (TGFBI), were identified and may play critical roles in the synergy of DAC and CDDP in UC. | Cisplatin | transforming growth factor beta induced | Homo sapiens |
| 3 | The results showed that several key regulatory genes, such as interleukin 24(IL24), fibroblast growth factor 1(FGF1), and transforming growth factor beta-induced (TGFBI), were identified and may play critical roles in the synergy of DAC and CDDP in UC. | Cisplatin | transforming growth factor beta induced | Homo sapiens |
| 4 | Our results suggested that TGF-beta1 stimulates the phosphorylation levels of ERK1/2 and p38 via increasing TGFBI expression, TGFBI-MAPK signaling pathway plays an important role in the synergy of DAC and CDDP against UC. | Cisplatin | transforming growth factor beta induced | Homo sapiens |
| 5 | Our results suggested that TGF-beta1 stimulates the phosphorylation levels of ERK1/2 and p38 via increasing TGFBI expression, TGFBI-MAPK signaling pathway plays an important role in the synergy of DAC and CDDP against UC. | Cisplatin | transforming growth factor beta induced | Homo sapiens |
| 6 | Therefore, we revealed the synergistic mechanism of DAC and CDDP in UC, several key regulatory genes play critical roles in the synergy of combined treatment, and TGFBI-MAPK signaling pathway may be an important potential target of these two agents. | Cisplatin | transforming growth factor beta induced | Homo sapiens |