Title : Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line.

Pub. Date : 2022 Feb 15

PMID : 34875337






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Although they have high specificity for PDE5, these inhibitors are suspected to cross-interact also with cyclic adenosine monophosphate (cAMP)-specific PDEs, inducing the intracellular accumulation of this cyclic nucleotide and related testosterone increase, positively impacting male reproductive parameters. Testosterone phosphodiesterase 5A Homo sapiens