Protein Name | phosphodiesterase 5A |
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Organism | Homo sapiens |
Gene ID | 8654 |
Gene Symbol | PDE5A |
UniProt | O76074 (PDE5A_HUMAN), G5E9C5 (G5E9C5_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
426
Total Number of Articles : 1336 |
Description |
phosphodiesterase 5A |
Gene Summary |
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
synonyms |
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Properties | |