Protein Name phosphodiesterase 5A
Organism Homo sapiens
Gene ID 8654
Gene Symbol

PDE5A

UniProt O76074 (PDE5A_HUMAN), G5E9C5 (G5E9C5_HUMAN)
Relationships Total Number of functionally related compound(s) : 426
Total Number of Articles : 1336
Description

phosphodiesterase 5A

Gene Summary

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

synonyms
  • cGMP-specific 3',5'-cyclic phosphodiesterase
  • cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase
  • cGMP-specific phosphodiesterase PDE5A2
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Properties