Pub. Date : 2022 Jan
PMID : 34812580
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Effect of Oral Letermovir Administration on the Pharmacokinetics of a Single Oral Dose of P-Glycoprotein Substrate Digoxin in Healthy Volunteers. | letermovir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | In vitro, letermovir is a substrate and potential modulator of P-glycoprotein. | letermovir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | The potential of letermovir to alter the pharmacokinetics of digoxin (a P-glycoprotein substrate) upon coadministration in healthy subjects was therefore investigated in a phase 1 trial (EudraCT: 2011-004516-39). | letermovir | ATP binding cassette subfamily B member 1 | Homo sapiens |