Title : Role of COMT V158M Polymorphism in the Development of Dystonia after Administration of Antipsychotic Drugs.

Pub. Date : 2021 Sep 29

PMID : 34679357






3 Functional Relationships(s)
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1 The catechol O-methyltransferase (COMT) gene is located within the 22q11.2 region, and its product is an enzyme involved in transferring a methyl group from S-adenosylmethionine to catecholamines, including dopamine. Dopamine catechol-O-methyltransferase Homo sapiens
2 The catechol O-methyltransferase (COMT) gene is located within the 22q11.2 region, and its product is an enzyme involved in transferring a methyl group from S-adenosylmethionine to catecholamines, including dopamine. Dopamine catechol-O-methyltransferase Homo sapiens
3 Studies showed that COMT Val158Met polymorphism modifies enzymatic activity and, consequently, synaptic dopamine concentration in specific brain areas. Dopamine catechol-O-methyltransferase Homo sapiens