Pub. Date : 2021
PMID : 34650915
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, non-iodide-avid metastases of DTC which is dedifferentiated do not respond to stimulation by high levels of TSH, suggesting abnormal TSH-TSHR signal transduction in cancer cells. | Thyrotropin | thyroid stimulating hormone receptor | Homo sapiens |
| 2 | Therefore, in this study, we aimed to explore the role of abnormal TSH-TSHR signaling activation in regulating iodide uptake and cell mobility in thyroid cancer and its relationship with PI3K/AKT/mTOR signaling. | Thyrotropin | thyroid stimulating hormone receptor | Homo sapiens |
| 3 | We found that in thyroid cancer cells, TSH binds TSHR coupled to the Galpha12/13 protein and then activates RhoA through interacting with leukemia associated RhoA guanine exchange factor (LARG). | Thyrotropin | thyroid stimulating hormone receptor | Homo sapiens |