Title : MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia.

Pub. Date : 2021

PMID : 34568318






1 Functional Relationships(s)
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1 To overcome this adaptation, we employed the BH3 mimetic S63845, a specific MCL-1 inhibitor, and evaluated its sequential addition to both kinase inhibitors to overcome resistance. S63845 MCL1 apoptosis regulator, BCL2 family member Homo sapiens