Pub. Date : 2021 Sep 14
PMID : 34521464
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BPDE is known to form an adduct at the guanines in a number of RAS gene sites, KRAS codons 12, 13 and 14, NRAS codon 12, and HRAS codons 12 and 14. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | KRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | CONCLUSIONS: We conclude that G:C > T:A mutations at KRAS codon 12 in the tumours of lung cancer patients (who smoke), proposed to be predominantly caused by BPDE, are due to the effect of the interaction methyl group at the C5 position of the thymine base in the KRAS sequence with the BPDE carcinogen investigated causing increased distortion. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | KRAS proto-oncogene, GTPase | Homo sapiens |
| 3 | CONCLUSIONS: We conclude that G:C > T:A mutations at KRAS codon 12 in the tumours of lung cancer patients (who smoke), proposed to be predominantly caused by BPDE, are due to the effect of the interaction methyl group at the C5 position of the thymine base in the KRAS sequence with the BPDE carcinogen investigated causing increased distortion. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | KRAS proto-oncogene, GTPase | Homo sapiens |
| 4 | CONCLUSIONS: We conclude that G:C > T:A mutations at KRAS codon 12 in the tumours of lung cancer patients (who smoke), proposed to be predominantly caused by BPDE, are due to the effect of the interaction methyl group at the C5 position of the thymine base in the KRAS sequence with the BPDE carcinogen investigated causing increased distortion. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | KRAS proto-oncogene, GTPase | Homo sapiens |
| 5 | CONCLUSIONS: We conclude that G:C > T:A mutations at KRAS codon 12 in the tumours of lung cancer patients (who smoke), proposed to be predominantly caused by BPDE, are due to the effect of the interaction methyl group at the C5 position of the thymine base in the KRAS sequence with the BPDE carcinogen investigated causing increased distortion. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | KRAS proto-oncogene, GTPase | Homo sapiens |