PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34521464-3 2021 BPDE is known to form an adduct at the guanines in a number of RAS gene sites, KRAS codons 12, 13 and 14, NRAS codon 12, and HRAS codons 12 and 14. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 0-4 KRAS proto-oncogene, GTPase Homo sapiens 79-83 34521464-5 2021 CONCLUSIONS: We conclude that G:C > T:A mutations at KRAS codon 12 in the tumours of lung cancer patients (who smoke), proposed to be predominantly caused by BPDE, are due to the effect of the interaction methyl group at the C5 position of the thymine base in the KRAS sequence with the BPDE carcinogen investigated causing increased distortion. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 158-162 KRAS proto-oncogene, GTPase Homo sapiens 53-57 34521464-5 2021 CONCLUSIONS: We conclude that G:C > T:A mutations at KRAS codon 12 in the tumours of lung cancer patients (who smoke), proposed to be predominantly caused by BPDE, are due to the effect of the interaction methyl group at the C5 position of the thymine base in the KRAS sequence with the BPDE carcinogen investigated causing increased distortion. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 158-162 KRAS proto-oncogene, GTPase Homo sapiens 264-268 34521464-5 2021 CONCLUSIONS: We conclude that G:C > T:A mutations at KRAS codon 12 in the tumours of lung cancer patients (who smoke), proposed to be predominantly caused by BPDE, are due to the effect of the interaction methyl group at the C5 position of the thymine base in the KRAS sequence with the BPDE carcinogen investigated causing increased distortion. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 287-291 KRAS proto-oncogene, GTPase Homo sapiens 53-57 34521464-5 2021 CONCLUSIONS: We conclude that G:C > T:A mutations at KRAS codon 12 in the tumours of lung cancer patients (who smoke), proposed to be predominantly caused by BPDE, are due to the effect of the interaction methyl group at the C5 position of the thymine base in the KRAS sequence with the BPDE carcinogen investigated causing increased distortion. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 287-291 KRAS proto-oncogene, GTPase Homo sapiens 264-268