Pub. Date : 2021 Oct 13
PMID : 34493542
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CD38 shows increased expression in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination; in addition, CD38 is the main nicotinamide adenine dinucleotide (NAD+)-depleting enzyme in the CNS. | NAD | CD38 antigen | Mus musculus |
| 2 | CD38 shows increased expression in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination; in addition, CD38 is the main nicotinamide adenine dinucleotide (NAD+)-depleting enzyme in the CNS. | NAD | CD38 antigen | Mus musculus |
| 3 | CD38 shows increased expression in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination; in addition, CD38 is the main nicotinamide adenine dinucleotide (NAD+)-depleting enzyme in the CNS. | NAD | CD38 antigen | Mus musculus |
| 4 | CD38 shows increased expression in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination; in addition, CD38 is the main nicotinamide adenine dinucleotide (NAD+)-depleting enzyme in the CNS. | NAD | CD38 antigen | Mus musculus |
| 5 | We demonstrate that CD38-catalytically inactive mice are substantially protected from high fat-induced NAD+ depletion, oligodendrocyte loss, oxidative damage, and astrogliosis. | NAD | CD38 antigen | Mus musculus |
| 6 | A CD38 inhibitor, 78c, increased NAD+ and attenuated neuroinflammatory changes induced by saturated fat applied to astrocyte cultures. | NAD | CD38 antigen | Mus musculus |
| 7 | Our findings suggest high fat diet impairs oligodendrocyte survival and differentiation through astrocyte-linked mechanisms mediated by the NAD+ase CD38 and highlight CD38 inhibitors as potential therapeutic candidates to improve myelin regeneration.SIGNIFICANCE STATEMENTMyelin disturbances and oligodendrocyte loss can leave axons vulnerable leading to permanent neurologic deficits. | NAD | CD38 antigen | Mus musculus |
| 8 | We demonstrate that restoring nicotinamide adenine dinucleotide (NAD+) levels via genetic inactivation of CD38 can overcome these effects. | NAD | CD38 antigen | Mus musculus |
| 9 | We demonstrate that restoring nicotinamide adenine dinucleotide (NAD+) levels via genetic inactivation of CD38 can overcome these effects. | NAD | CD38 antigen | Mus musculus |