Protein Name CD38 antigen
Organism Mus musculus
Gene ID 12494
Gene Symbol

Cd38

UniProt P56528 (CD38_MOUSE), Q4FJL8 (Q4FJL8_MOUSE), Q3UCS6 (Q3UCS6_MOUSE)
Relationships Total Number of functionally related compound(s) : 182
Total Number of Articles : 235
Description

CD38 antigen

Gene Summary

This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors. [provided by RefSeq, Sep 2015]

synonyms
  • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
  • 2'-phospho-ADP-ribosyl cyclase
  • 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
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Properties