PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34493542-2	2021	CD38 shows increased expression in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination; in addition, CD38 is the main nicotinamide adenine dinucleotide (NAD+)-depleting enzyme in the CNS.	NAD	150-183	CD38 antigen	Mus musculus	0-4	
34493542-2	2021	CD38 shows increased expression in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination; in addition, CD38 is the main nicotinamide adenine dinucleotide (NAD+)-depleting enzyme in the CNS.	NAD	150-183	CD38 antigen	Mus musculus	133-137	
34493542-2	2021	CD38 shows increased expression in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination; in addition, CD38 is the main nicotinamide adenine dinucleotide (NAD+)-depleting enzyme in the CNS.	NAD	185-189	CD38 antigen	Mus musculus	0-4	
34493542-2	2021	CD38 shows increased expression in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination; in addition, CD38 is the main nicotinamide adenine dinucleotide (NAD+)-depleting enzyme in the CNS.	NAD	185-189	CD38 antigen	Mus musculus	133-137	
34493542-5	2021	We demonstrate that CD38-catalytically inactive mice are substantially protected from high fat-induced NAD+ depletion, oligodendrocyte loss, oxidative damage, and astrogliosis.	NAD	103-107	CD38 antigen	Mus musculus	20-24	
34493542-6	2021	A CD38 inhibitor, 78c, increased NAD+ and attenuated neuroinflammatory changes induced by saturated fat applied to astrocyte cultures.	NAD	33-37	CD38 antigen	Mus musculus	2-6	
34493542-11	2021	Our findings suggest high fat diet impairs oligodendrocyte survival and differentiation through astrocyte-linked mechanisms mediated by the NAD+ase CD38 and highlight CD38 inhibitors as potential therapeutic candidates to improve myelin regeneration.SIGNIFICANCE STATEMENTMyelin disturbances and oligodendrocyte loss can leave axons vulnerable leading to permanent neurologic deficits.	NAD	140-144	CD38 antigen	Mus musculus	148-152	
34493542-13	2021	We demonstrate that restoring nicotinamide adenine dinucleotide (NAD+) levels via genetic inactivation of CD38 can overcome these effects.	NAD	30-63	CD38 antigen	Mus musculus	106-110	
34493542-13	2021	We demonstrate that restoring nicotinamide adenine dinucleotide (NAD+) levels via genetic inactivation of CD38 can overcome these effects.	NAD	65-69	CD38 antigen	Mus musculus	106-110