Pub. Date : 2022 Jan
PMID : 34313822
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High UA concentrations decrease insulin-induced NO synthesis within the endothelial cells by interfering with insulin signaling at either the receptor or post-receptor levels (i.e., proximal and distal steps). | Uric Acid | insulin | Homo sapiens |
| 2 | High UA concentrations decrease insulin-induced NO synthesis within the endothelial cells by interfering with insulin signaling at either the receptor or post-receptor levels (i.e., proximal and distal steps). | Uric Acid | insulin | Homo sapiens |
| 3 | At the proximal post-receptor level, UA impairs the function of the insulin receptor substrate (IRS) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) in the insulin signaling pathway. | Uric Acid | insulin | Homo sapiens |
| 4 | Clinically, UA-induced endothelial insulin resistance is translated into impaired endothelial function, impaired NO-dependent vasodilation, and the development of systemic insulin resistance. | Uric Acid | insulin | Homo sapiens |
| 5 | Clinically, UA-induced endothelial insulin resistance is translated into impaired endothelial function, impaired NO-dependent vasodilation, and the development of systemic insulin resistance. | Uric Acid | insulin | Homo sapiens |