PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34313822-4	2022	High UA concentrations decrease insulin-induced NO synthesis within the endothelial cells by interfering with insulin signaling at either the receptor or post-receptor levels (i.e., proximal and distal steps).	Uric Acid	5-7	insulin	Homo sapiens	32-39	
34313822-4	2022	High UA concentrations decrease insulin-induced NO synthesis within the endothelial cells by interfering with insulin signaling at either the receptor or post-receptor levels (i.e., proximal and distal steps).	Uric Acid	5-7	insulin	Homo sapiens	110-117	
34313822-5	2022	At the proximal post-receptor level, UA impairs the function of the insulin receptor substrate (IRS) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) in the insulin signaling pathway.	Uric Acid	37-39	insulin	Homo sapiens	172-179	
34313822-7	2022	Clinically, UA-induced endothelial insulin resistance is translated into impaired endothelial function, impaired NO-dependent vasodilation, and the development of systemic insulin resistance.	Uric Acid	12-14	insulin	Homo sapiens	35-42	
34313822-7	2022	Clinically, UA-induced endothelial insulin resistance is translated into impaired endothelial function, impaired NO-dependent vasodilation, and the development of systemic insulin resistance.	Uric Acid	12-14	insulin	Homo sapiens	172-179