Pub. Date : 2021
PMID : 34306319
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rotenone-induced LRRK2 upregulation impaired the clearance of alpha-syn fibrils. | Rotenone | synuclein alpha | Homo sapiens |
| 2 | Treatment with LRRK2 inhibitor mitigated rotenone-induced cellular senescence and alpha-syn accumulation. | Rotenone | synuclein alpha | Homo sapiens |
| 3 | Conclusions: Rotenone-induced upregulation of LRRK2 kinase activity promoted cellular senescence, which enhanced alpha-syn accumulation. | Rotenone | synuclein alpha | Homo sapiens |