Title : Sex Differences in Tolerance to Delta-9-Tetrahydrocannabinol in Mice With Cisplatin-Evoked Chronic Neuropathic Pain.

Pub. Date : 2021

PMID : 34250019






3 Functional Relationships(s)
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1 Our previous work found that male mice expressing a desensitization resistant form (S426A/S430A) of the type 1 cannabinoid receptor (CB1R) show delayed tolerance and increased sensitivity to the antinociceptive effects of delta-9-tetrahydrocannabinol ( 9-THC). Dronabinol cannabinoid receptor 1 (brain) Mus musculus
2 Our previous work found that male mice expressing a desensitization resistant form (S426A/S430A) of the type 1 cannabinoid receptor (CB1R) show delayed tolerance and increased sensitivity to the antinociceptive effects of delta-9-tetrahydrocannabinol ( 9-THC). Dronabinol cannabinoid receptor 1 (brain) Mus musculus
3 The anti-allodynic effects of 9-THC were blocked following pretreatment with the CB1R antagonist, rimonabant, and partially blocked following pretreatment with the CB2R inverse agonist, SR144528. Dronabinol cannabinoid receptor 1 (brain) Mus musculus