Pub. Date : 2021 Jun
PMID : 34237977
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexmedetomidine attenuates cerebral ischemia-reperfusion injury in rats by inhibiting the JNK pathway. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | This study was conducted to explore the effects of dexmedetomidine (Dex) on the c-Jun N-terminal kinase (JNK) pathway in CI/RI, and to provide a theoretical basis for the recovery of brain function after cerebral ischemia. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | This study was conducted to explore the effects of dexmedetomidine (Dex) on the c-Jun N-terminal kinase (JNK) pathway in CI/RI, and to provide a theoretical basis for the recovery of brain function after cerebral ischemia. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 4 | RESULTS: Compared with the Sham group, the rats in I/R, I/R + Dex, I/R + Yoh + Dex, and I/R + SP600125 groups developed hemiparesis of the left forelimb at different levels with a higher neurological deficit score, brain water content, infarct volume, and markedly upregulated expression of cleaved caspase-3, p-JNK (P<0.05). | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 5 | RESULTS: Compared with the Sham group, the rats in I/R, I/R + Dex, I/R + Yoh + Dex, and I/R + SP600125 groups developed hemiparesis of the left forelimb at different levels with a higher neurological deficit score, brain water content, infarct volume, and markedly upregulated expression of cleaved caspase-3, p-JNK (P<0.05). | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 6 | Dex can alleviate cerebral CI/RI in rats by increasing alpha2-adrenergic receptor and blocking JNK phosphorylation and activation of caspase-3. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |