PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34237977-0 2021 Dexmedetomidine attenuates cerebral ischemia-reperfusion injury in rats by inhibiting the JNK pathway. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 90-93 34237977-2 2021 This study was conducted to explore the effects of dexmedetomidine (Dex) on the c-Jun N-terminal kinase (JNK) pathway in CI/RI, and to provide a theoretical basis for the recovery of brain function after cerebral ischemia. Dexmedetomidine 51-66 mitogen-activated protein kinase 8 Rattus norvegicus 80-103 34237977-2 2021 This study was conducted to explore the effects of dexmedetomidine (Dex) on the c-Jun N-terminal kinase (JNK) pathway in CI/RI, and to provide a theoretical basis for the recovery of brain function after cerebral ischemia. Dexmedetomidine 68-71 mitogen-activated protein kinase 8 Rattus norvegicus 80-103 34237977-7 2021 RESULTS: Compared with the Sham group, the rats in I/R, I/R + Dex, I/R + Yoh + Dex, and I/R + SP600125 groups developed hemiparesis of the left forelimb at different levels with a higher neurological deficit score, brain water content, infarct volume, and markedly upregulated expression of cleaved caspase-3, p-JNK (P<0.05). Dexmedetomidine 62-65 mitogen-activated protein kinase 8 Rattus norvegicus 312-315 34237977-7 2021 RESULTS: Compared with the Sham group, the rats in I/R, I/R + Dex, I/R + Yoh + Dex, and I/R + SP600125 groups developed hemiparesis of the left forelimb at different levels with a higher neurological deficit score, brain water content, infarct volume, and markedly upregulated expression of cleaved caspase-3, p-JNK (P<0.05). Dexmedetomidine 79-82 mitogen-activated protein kinase 8 Rattus norvegicus 312-315 34237977-12 2021 Dex can alleviate cerebral CI/RI in rats by increasing alpha2-adrenergic receptor and blocking JNK phosphorylation and activation of caspase-3. Dexmedetomidine 0-3 mitogen-activated protein kinase 8 Rattus norvegicus 95-98