| Protein Name | mitogen-activated protein kinase 8 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 116554 |
| Gene Symbol | Mapk8 |
| UniProt | P49185 (MK08_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
1068
Total Number of Articles : 1786 |
Description |
mitogen-activated protein kinase 8 |
| Gene Summary |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012] |
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