Pub. Date : 2021 Dec
PMID : 34180037
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phase I study of daily and weekly regimens of the orally administered MDM2 antagonist idasanutlin in patients with advanced tumors. | RG7388 | MDM2 proto-oncogene | Homo sapiens |
| 2 | Aim The oral MDM2 antagonist idasanutlin inhibits the p53-MDM2 interaction, enabling p53 activation, tumor growth inhibition, and increased survival in xenograft models. | RG7388 | MDM2 proto-oncogene | Homo sapiens |
| 3 | Aim The oral MDM2 antagonist idasanutlin inhibits the p53-MDM2 interaction, enabling p53 activation, tumor growth inhibition, and increased survival in xenograft models. | RG7388 | MDM2 proto-oncogene | Homo sapiens |