Title : Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation.

Pub. Date : 2021 Sep

PMID : 34175720






2 Functional Relationships(s)
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Protein Name
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1 Doxorubicin as a universal anticancer drug and sorafenib as a potent VEGFR-2 inhibitor were used as positive controls. Sorafenib kinase insert domain receptor Homo sapiens
2 Compounds 15 and 17b potently inhibited VEGFR-2 at lower IC50 values of 1.09 and 1.19 microM, respectively, compared to sorafenib (IC50 = 1.27 microM). Sorafenib kinase insert domain receptor Homo sapiens