Title : Lycopene prevents oxygen-glucose deprivation-induced autophagic death in SH-SY5Y cells via inhibition of the oxidative stress-activated AMPK/mTOR pathway.

Pub. Date : 2021 Aug

PMID : 34165166






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Lycopene prevents oxygen-glucose deprivation-induced autophagic death in SH-SY5Y cells via inhibition of the oxidative stress-activated AMPK/mTOR pathway. Lycopene protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 Mechanistically, it was suggested that lycopene inhibited OGD-induced activation of the AMPK/mTOR pathway via attenuation of oxidative stress by maintaining the intracellular antioxidant glutathione (GSH). Lycopene protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
3 Collectively, the present study demonstrated that lycopene protected SH-SY5Y cells against OGD-induced autophagic death by inhibiting oxidative stress-dependent activation of the AMPK/mTOR pathway. Lycopene protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens