Title : Metformin Adjunct With Antineoplastic Agents for the Treatment of Lung Cancer: A Meta-Analysis of Randomized Controlled Trials and Observational Cohort Studies.

Pub. Date : 2021

PMID : 34149406






2 Functional Relationships(s)
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1 Metformin could enhance the anticancer effects of standard antineoplastic agents (traditional chemotherapy drugs, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), or immune checkpoint inhibitors (ICIs)); however, it is unclear whether metformin can be combined with antineoplastic agents in the treatment of lung cancer. Metformin epidermal growth factor receptor Homo sapiens
2 Compared to standard antineoplastic agents alone (traditional chemotherapy drugs, EGFR-TKIs or ICIs), the antineoplastic agents combined with metformin significantly improved OS (HR 0.73, 95% CI 0.66-0.81, p < 0.00001) and PFS (HR 0.72, 95% CI 0.59-0.88, p = 0.001); a similar association was found in observational evidence. Metformin epidermal growth factor receptor Homo sapiens